Table 4.
Animal models for ototoxicity.
| Species | AGs (dose) | Diuretics (dose) | Route | Reference |
|---|---|---|---|---|
| C | gentamicin (10, 20, 40, 125 mg/kg; single injection) | ethacrynic acid (40 mg/kg) | i.m. | (McFadden et al., 2002) |
| M | kanamycin (1000 mg/kg; single injection) | bumetanide (50 mg/kg) | i.p. | (Taylor et al., 2008) |
| M, R | kanamycin (400–900 mg/kg; 15d, twice daily) | - | s.c. | (Wu et al., 2001) |
| C | gentamicin (125 mg/kg; single injection) | ethacrynic acid (40 mg/kg) | i.m. | (Ding et al., 2010) |
| R | kanamycin (500 mg/kg; single injection) | ethacrynic acid (75 mg/kg) | i.m. | (Liu et al., 2011) |
| GP | gentamicin (100 mg/kg; single injection) | - | i.p. | (Imamura and Adams, 2003) |
| R | amikacin (200 mg/kg; 14, 28d, once daily) | - | i.m. | (El-Anwar et al., 2018) |
| GP | gentamicin (40, 80 mg/kg; 10d, once daily) | - | s.c. | (Bezdjian et al., 2015) |
| M | kanamycin (420, 550, 600 mg/kg; 3, 5, 7, 10, 14d, once daily) | furosemide (130 mg/kg) | s.c. | (Ju et al., 2017) |
| M | kanamycin (700, 1,000 mg/kg; single injection) | furosemide (100 mg/kg) | i.p. | (Jansen et al., 2013) |
| R | amikacin (200 mg/kg; 14d, once daily) | - | i.m. | (El-Anwar et al., 2016) |
| GP | amikacin (20, 400 mg/kg; 12, 30 days, once daily) | - | i.m. | (Oliveira et al., 2004) |
| M | kanamycin (900 mg/kg; 15d, twice daily) | furosemide (50 mg/kg) | i.p. | (Hirose and Sato, 2011) |
| G | gentamicin or kanamycin (4–500 mg/kg; single injection) | bumetanide (50 mg/kg) or furosemide (100 mg/kg) | s.c. | (Abbas and Rivolta, 2015) |
| GP | kanamycin (200 mg/kg; single injection) | furosemide (100 mg/kg) | s.c. | (Havenith et al., 2013) |
| GP | amikacin (200 mg/kg; 14 days, once daily) | - | s.c. | (Dirain et al., 2018) |
| R | amikacin (600 mg/kg; 14 days, once daily) | - | i.m. | (Aksoy et al., 2014) |
| GP, R | kanamycin (400 mg/kg; single injection) | ethacrynic acid (50 mg/kg) | s.c. | (Yamasoba et al., 2003) |
| R | tobramycin (160 mg/kg; 14 days, once daily) | - | s.c. | (Asplund et al., 2009) |
| M | kanamycin (1,000 mg/kg; single injection) | furosemide (400 mg/kg) | s.c. | (Schmitz et al., 2014) |
| M | kanamycin (1,000 mg/kg; single injection) | furosemide (500 mg/kg) | s.c. | (Fernandes and Lin, 2014) |
| R | kanamycin (500 mg/kg; single injection) | furosemide (200 mg/kg) | i.p. | (Chen et al., 2020) |
| M | kanamycin (700 mg/kg; 14d, twice daily) | - | s.c | (Koo et al., 2015) |
(C, chinchilla; M, mouse; R, rat; GP, guinea pig; G, gerbil; i.m., intramuscular injection; i.p., intraperitoneal injection; s.c., subcutaneous injection)