Table 3.
Diagnostic performance of hepatic native T1 and MRI-derived extracellular volume fraction as well as clinical scores of liver disease severity for the differentiation between patients with liver cirrhosis of Child–Pugh classes B and C.
| AUC | Cutoff value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) | |
|---|---|---|---|---|---|---|---|
| Native T1 | 0.910 | > 722 ms | 100.0 (72.2–100.0) | 82.8 (65.5–94.2) | 66.7 (41.7–84.8) | 100 (86.2–100.0) | 87.2 (73.3–94.4) |
| ECV | 0.944 | > 46.85% | 88.9 (56.5–98.0) | 90.0 (74.4–96.5) | 72.7 (43.4–90.3) | 96.4 (82.3–99.4) | 89.7 (76.4–95.9) |
| MELD score | 0.795 | > 10.5 | 100.0 (64.6–100.0) | 50.0 (33.6–66.4) | 30.4 (15.6–50.9) | 100.0 (80.6–100.0) | 59.0 (43.4–72.9) |
| APRI score | 0.634 | > 1.176 | 71.4 (35.9–91.8) | 56.3 (39.3–71.8) | 26.3 (11.8–48.8) | 90.0 (69.9–97.2) | 59.0 (43.4–72.9) |
| FIB-4 score | 0.607 | > 5.208 | 85.7 (48.7–97.4) | 59.4 (42.3–74.5) | 31.6 (15.4–54.0) | 95.0 (76.4–99.1) | 64.1 (48.4–77.3) |
ECV extracellular volume fraction, MELD model of end-stage liver disease, APRI score aspartate aminotransferase to platelet ratio index, FIB-4 score fibrosis 4 score, AUC area under the curve, PPV positive predictive value, NPV negative predictive value.