Table 1.

Examples of miRNAs implicated in ferroptosis regulation in cancer.

miRNA	Role in ferroptosis	Mechanism of action	Reference
miR-375	Induces ferroptosis in gastric cancer	Downregulates SLC7A11	[34]
miR-4715-3p	Induces ferroptosis in gastric and esophageal carcinomas	Downregulates AURKA and GPX4 expression	[170]
miR-214-3p	Induces ferroptosis in HCC	Downregulates ATF4 and SLC7A11	[35]
miR-101-3p	Induces ferroptosis in lung cancer	Downregulates TBLR1, NF-κB, GPX4 and PTGS2 expression	[26]
miR-324-3p	Induces ferroptosis in LUAD	Downregulates GPX4	[27]
miR-324-3p	Induces ferroptosis in breast cancer	Downregulates GPX4	[28]
miR-5096	Induces ferroptosis in breast cancer	Downregulates SLC7A11	[36]
miR-1287-5p	Induces ferroptosis in osteosarcoma	Downregulates GPX4	[171]
miR-137	Inhibits ferroptosis in melanoma	Downregulates SLC1A5	[93]
miR-9	Inhibits ferroptosis in melanoma	Downregulates GOT1, inhibits glutaminolysis	[172]
miR-130b-3p	Inhibits ferroptosis in melanoma	Downregulates DKK1, upregulates NRF2 and HO-1 expression	[173]
miR-103a-3p	Inhibits ferroptosis in gastric cancer	Downregulates GLS2, prevents hydrolysis of glutamine to glutamate	[174]
miR-522	Inhibits ferroptosis in gastric cancer	Downregulates ALOX15	[60]
miR-23a-3p	Inhibits ferroptosis in HCC	Downregulates ACSL4	[54]
miR-4443	Inhibits ferroptosis in NSCLC	Downregulates m6A, upregulates FSP1	[46]
miR-424-5p	Inhibits ferroptosis in ovarian cancer	Downregulates ACSL4	[55]
miR-7-5p	Inhibits ferroptosis in ovarian, oral squamous cell and HCC	Downregulates mitoferrin, reduces mitochondrial iron levels	[99]
miR-7-5p	Inhibits ferroptosis in cervical and oral squamous carcinomas	Upregulates ferritin, downregulates ALOX12 expression	[59]