Table 2.
Examples of lncRNAs implicated in ferroptosis regulation in cancer.
| lncRNA | Role in ferroptosis | Mechanism of action | Reference |
|---|---|---|---|
| P53RRA (LINC00472) | Induces ferroptosis in lung cancer | Downregulates SCL7A11 | [38] |
| MT1DP | Induces ferroptosis in NSCLC | Stabilizes miR-365a-3p, downregulates NRF2 | [113] |
| GABPB1-AS1 | Induces ferroptosis in HCC | Inhibits GABPB1 translation, downregulates GABPB1 and PRDX5 | [112] |
| LINC00618 | Induces ferroptosis in leukemias | Downregulates SLC7A11 via attenuation of LSH expression | [37] |
| LINC00336 | Inhibits ferroptosis in lung cancer | Stabilized by ELAVL1 and LSH. Sponges miRNA6852, upregulates CBS | [114] |
| NEAT1 | Inhibits ferroptosis in NSCLC | Downregulates ACSL4 expression | [56] |
| H19 | Inhibits ferroptosis in breast cancer | Inhibits production of lipid ROS and induces production of GSH | [175] |
| lncPVT1 | Inhibits ferroptosis in HCC | Sponges miR-214-3p, upregulates GPX4 | [29] |
| OIP5-AS1 | Inhibits ferroptosis in prostate cancer | Sponges miR-128-3p, upregulates SLC7A11 expression | [39] |
| RP11-89 | Inhibits ferroptosis in bladder cancer | Sponges miR-129-5p, upregulates PROM2 which induces iron export | [176] |
| MEG8 | Inhibits ferroptosis in benign hemangioma | Sponged by miR-497-5p. Upregulates SLC7A11 and GPX4 expression | [177] |