Table 3.

Examples of circRNAs implicated in ferroptosis regulation in cancer.

circRNA	Role in ferroptosis	Mechanism of action	Reference
cIARS	Induces ferroptosis and ferritinophagy in sorafenib-treated HCC	Interacts with ALKBH5, improves Bcl-2 mRNA stability, enhances Bcl-2/BECN1 interaction	[139]
circ_0000190	Induces ferroptosis in gastric cancer	Sponges miR-382-5p, upregulates ZNRF3, inhibits Wnt/β-catenin signaling	[178]
circKDM4C	Induces ferroptosis in AML	Sponges miRNA let-7b-5p. When present, upregulates ACSL4, PTGS2 and p53, and downregulates GPX4 and FTH1	[32]
circ-TTBK2	Inhibits ferroptosis in glioma	Sponges miR-761, upregulates ITGB8 expression	[179]
circCDK14	Inhibits ferroptosis in glioma	Sponges miR-3938, upregulates PDGFRA, GPX4 and SLC7A11 expression	[30]
circKIF4A	Inhibits ferroptosis in papillary thyroid cancer	Sponges miR-1231, upregulates GPX4 expression	[146]
circ_0067934	Inhibits ferroptosis in papillary and follicular thyroid cancers	Sponges miR-545-3p, upregulates SLC7A11 expression	[144]
circDTL	Inhibits ferroptosis in NSCLC	Sponges miR-1287-5p, upregulates GPX4	[31]
circRHOT1	Inhibits ferroptosis in breast cancer	Sponges miR-106a-5p, upregulates STAT3	[180]
circGFRA1	Inhibits ferroptosis in breast cancer	Sponges miR‐1228, upregulates AIFM2 and GPX4 expression	[181]
circPVT1	Inhibits ferroptosis in esophageal cancer	Sponges miR-30a-5p, upregulates FZD3, GPX4 and SLC7A11 expression	[40]
circIL4R	Inhibits ferroptosis in HCC	Sponges miR-541-3p, upregulates GPX4 expression	[182]
circ0097009	Inhibits ferroptosis in HCC	Sponges miR-1261, upregulates SLC7A11	[143]
circABCB10	Inhibits ferroptosis in CRC	Sponges miR-326, upregulates CCL5	[141]
circ_0007142	Inhibits ferroptosis in CRC	Sponges miR-874-3p, upregulates GDPD5	[183]
circEPSTI1	Inhibits ferroptosis in cervical cancer	Sponges miR-375, miR-409-3p and miR-515-5p, upregulates SLC7A11 expression	[41]