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. Author manuscript; available in PMC: 2023 Jun 2.
Published in final edited form as: Structure. 2022 May 2;30(6):886–899.e4. doi: 10.1016/j.str.2022.04.004

Figure 7. 2a-ATP, ITP, and XTP binding modes of PI5P4Kβ.

Figure 7.

(A) Interaction of 2a-ATP to PI5P4Kβ (PDB ID 7EM3). (B) Interactions of the ITP to PI5P4Kβ(PDB ID 7EM1). (C and D) Interactions of XTP to PI5P4Kβ (C) in the mode similar to GTP (GTP-binding mode) and (D) in the mode unique to XTP (XTP-binding mode) (PDB ID 7EM2). Red dotted lines represent hydrogen bonds between the PNTs and PI5P4Kβ. As for the ITP complex, the water position visible with a lower σ value is also indicated with a gray circle. See also Fig. S4 for overlay of the 2a-ATP, ITP, and XTP binding modes with the ATP or GTP binding modes. See also Table S6 for structural statistics.