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. 2021 Dec 1;29(6):1176–1186. doi: 10.1038/s41418-021-00908-7

Fig. 4. The reduced sensitivity to TNF in Bcl-3-deficient mice is independent of lymphocytes.

Fig. 4

A Schematic showing that lethally irradiated WT and KO mice transplanted with wild-type bone marrow cells were injected intraperitoneally with T + D. B Survival of WT and KO recipients treated with T + D was monitored every 2 h for 2 days. C Schematic showing that lethally irradiated WT and KO mice transplanted with Bcl-3-deficient bone marrow were injected with T + D. D Survival of WT and KO recipients was monitored. E Liver tissues were collected and photographed at 4 h after injection. F H&E staining of livers of the recipients 4 h post injection (scale bar = 20 μm). G Immunohistochemical analysis of livers of the recipients were stained for cleaved Caspase 3 at 4 h after injection (scale bar = 100 μm). The integrated intensity is shown on the right. The results are shown as the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.