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. 2022 Mar 23;82(11):2047–2056. doi: 10.1158/0008-5472.CAN-21-3503

Figure 2.

Figure 2. Trained immunity. Challenge of innate immune cells and HSPCs with training stimuli induces changes in cell signaling and metabolism. Specific TFs, such as NF-κB or AP-1, and epigenetic enzymes, induce chromatin and DNA modifications, and regulate gene transcription. Expression of these genes in turn feeds the machinery of innate immunity and promotes cytokine secretion.

Trained immunity. Challenge of innate immune cells and HSPCs with training stimuli induces changes in cell signaling and metabolism. Specific TFs, such as NF-κB or AP-1, and epigenetic enzymes, induce chromatin and DNA modifications, and regulate gene transcription. Expression of these genes in turn feeds the machinery of innate immunity and promotes cytokine secretion.