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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Hypertension. 2022 May 5;79(7):1536–1547. doi: 10.1161/HYPERTENSIONAHA.121.18832

Figure 5. Endothelial MR deletion prevented leptin-mediated reduction in endothelial relaxation in pregnant mice.

Figure 5.

Vascular relaxation responses in thoracic aorta of KO+vehicle and KO+leptin pregnant mice (GD 18). Leptin infusion did not reduce endothelial-dependent relaxation responses to ACh in KO pregnant mice in the absence of or presence of LNAME preincubation (A). Leptin did not reduce SNP-mediated endothelial-independent relaxation responses in KO pregnant mice (B). Leptin infusion also did not increase vascular constriction responses to phenylephrine (Phe) (C) or KCl (D) in KO pregnant mice. N=6 KO+vehicle, N=4 KO+leptin. 2-way ANOVA with repeated measures.*P<0.05.