. Author manuscript; available in PMC: 2023 Jun 1.

Published in final edited form as: Psychopharmacology (Berl). 2022 Mar 7;239(6):1945–1976. doi: 10.1007/s00213-022-06083-y

Table 1.

Main enzymes involved in MDMA & psilocybin metabolism

	Metabolic enzymes

MDMA	CYP2D6 (auto inhibitor) CYP3A4 CYP2B6 CYP2C19 CYP1A2 COMT
Psilocybin/Psilocin	Alkaline phosphatase UGT1A10 UGT1A9 Aldehyde dehydrogenase MAO-A

Bold = primary metabolic enzyme(s)