Skip to main content
. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2022 Apr 22;149(6):1845–1854. doi: 10.1016/j.jaci.2022.04.012

Figure 2. Structure of two SCF isoforms.

Figure 2.

Two main SCF isoforms, SCF220 and SCF248, are produced by alternative splicing. Both SCF220 and SCF248 consist of an extracellular domain, a transmembrane domain and an intracellular tail. Exon 6 in SCF248 encodes a protease sensitive site that can be cleaved to generate soluble SCF165. Minor amounts of soluble SCF also can be generated from SCF220 by an alternative protease cleavage site encoded by exon 7 (not depicted). Biologically active SCF is a non-covalent dimer in either membrane-associated or soluble form.