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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: J Allergy Clin Immunol. 2022 Apr 22;149(6):1845–1854. doi: 10.1016/j.jaci.2022.04.012

Figure 3. Pleiotropic effects of SCF-KIT interactions on mast cell development and function.

Figure 3.

The binding of the SCF homodimer induces dimerization and phosphorylation of the KIT receptor, which can promote the differentiation, proliferation, maturation, and/or enhanced survival of cells in the MC lineage. SCF-KIT interactions can also activate MCs to express cellular functions and promote MC migration, chemotaxis, and adhesion, and, at high concentrations, MC degranulation and mediator release. P: phosphorylated tyrosine