Table 4:

Univariate and Multivariate Factors Associated with Renal Reduction of Intact FGF23, C-terminal FGF23, and Intact to C-terminal Ratio

Intact FGF23 Reduction
Variable	Univariate Analysis		Multivariate Analysis
	β (95% CI)	P-value	β (95% CI)	P-value
Creatinine reduction	4.84 (2.47, 7.21)	<0.001	3.08 (0.93, 5.24)	0.005
Intact PTH reduction	9.15 (7.11, 11.19)	<0.001	8.47 (6.43, 10.52)	<0.001
Calcium reduction	−1.48 (−4.38, 1.42)	0.313	−0.01 (−2.99, 2.98)	0.996
Phosphate reduction	1.77 (−0.69, 4.24)	0.159	0.45 (−2.09, 2.99)	0.729
α Klotho reduction	−0.07 (−0.25, 0.10)	0.405	−0.54 (−3.43, 2.36)	0.714
C-terminal FGF23 Reduction
Creatinine reduction	4.64 (2.92, 6.36)	<0.001	3.14 (1.66, 4.61)	<0.001
Intact PTH reduction	7.56 (6.12, 9.00)	<0.001	6.89 (5.50, 8.28)	<0.001
Calcium reduction	−1.75 (−4.18, 0.69)	0.158	−0.34 (−2.29, 1.61)	0.735
Phosphate reduction	1.24 (−0.61, 3.08)	0.191	−0.16 (−1.87, 1.56)	0.858
α Klotho reduction	−2.05 (−4.45, 0.34)	0.092	−1.05 (−2.65, 0.55)	0.198
Intact / C-terminal FGF23 Reduction
Creatinine reduction	0.07 (−1.20, 1.35)	0.912	−0.05 (−1.42, 1.32)	0.94
Intact PTH reduction	0.07 (−1.25, 1.35)	0.913	0.04 (−1.28, 1.36)	0.955
Calcium reduction	−0.45 (−1.73, 0.84)	0.497	−0.59 (−2.25, 1.07)	0.485
Phosphate reduction	0.35 (−0.93, 1.62)	0.595	0.07 (−1.50, 1.63)	0.935
α Klotho reduction	0.06 (−0.07, 0.18)	0.369	0.66 (−0.67, 1.99)	0.331

β* reflects % change in FGF23 clearance per 1SD higher of each variable