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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Proteins. 2022 Mar 11;90(7):1474–1485. doi: 10.1002/prot.26328

Figure 1:

Figure 1:

Epistasis scatterplots for binding (A) and folding (B). Both figures use a cutoff of 0.5 kcal/mol and show data characterized as no epistasis (black), positive epistasis (blue), and negative epistasis (red).