KEY RESOURCES TABLE.
| REAGENT or RESOURCE | SOURCE | IDENTIFIER |
|---|---|---|
| Antibodies | ||
| Anti-mouse CD31-FITC, Clone | BioLegend | 102506; RRID:AB_312913 |
| Anti-mouse CD31-APC, Clone | BioLegend | 102510; RRID:AB_312917 |
| MEC13.3 Anti-mouse CD45 -FITC, Clone 30- | BioLegend | 103108; RRID:AB_312973 |
| F11 Anti- mouse CD45-APC, Clone 30- | BioLegend | 103112; RRID:AB_312977 |
| F11 Anti- mouse Ly-6A/E(Sca1)-Pacific | BioLegend | 108120; RRID:AB_493273 |
| Blue, ClonAnti-mouse CD106 (VCAM1)D7 - | BioLegend | 105720; RRID:AB_2214046 |
| PE/CAnti-laminin 2a y7, Clone 429(MVCAM.A) | Abcam | 11576; RRID:AB_298180 |
| Anti-mouse p53 | Leica | NCL-L-p53-CM5p; |
| Anti-Acetyl-p53 (Lys379) | CST | RRID:AB_563933 2570S; RRID:AB_823591 |
| Anti-Acetylated Lysine | CST | 9441S; RRID:AB_331805 |
| Anti-OXCT1 | Abcam | 105320; RRID:AB_10712153 |
| Bacterial and Virus Strains | ||
| Biological Samples | ||
| Chemicals, Peptides, and Recombinant Proteins | ||
| Beta hydroxybutyrate (BHB) | Sigma-Aldrich | H6501 |
| Acetoacetate | Sigma-Aldrich | A8509 |
| Givinostat | Selleck Chemicals | S2170 |
| Droxinostat | Selleck Chemicals | S1422 |
| Entinostat | Selleck Chemicals | S1053 |
| Tacedenaline | Selleck Chemicals | S2818 |
| MC1568 | Selleck Chemicals | S1484 |
| 5-ethynyl-2’-deoxyuridine (EdU) | Invitrogen (ex vivo); Abcam (in vivo) |
C10339 (Invitrogen); ab146186 (Abcam) |
| Nutlin-3 | Selleck Chemicals | S1061 |
| 40,6-diamidino-2-phenylindole | Thermo Fisher | D1306 |
| (Propidium iodide DAPI) | Thermo Fisher | P3566 |
| Tamoxifen | Sigma | T5648 |
| 7-AAD | BioLegend | 640922 |
| Epigenetics Compound Library | Selleck Chemicals | L1900 |
| Syrosingopine | Sigma-Aldrich | SML1908 |
| AZD3965 | Selleck Chemicals | S7339 |
| DMSO | Sigma-Aldrich | 41639 |
| Critical Commercial Assays | ||
| In Situ Cell Death Detection Kit, | Sigma-Aldrich | 12156792910 |
| FITC Annexin V Apoptosis Detection | BioLegend | 640922 |
| Kit withClick-iT EdU Imaging Kit7-AAD | Thermo Fisher | C10340 |
| Deposited Data | ||
| RNA-Seq | NCBI Omnibus | GEO accession code GSE184821 |
| Raw Data for graphs and blots | Supplemental file Data S1 | |
| Experimental Models: Cell Lines | ||
| Experimental Models: Organisms/Strains | ||
| Mouse: C57BL/6J JAX or NIA | JAX or NIA | Catalog # 000664 RRID:IMSR_JAX:000664 |
| Mouse: B6.129P2-Trp53tm1Brn/J (or p53LoxP) | JAX | Catalog # 008462 RRID:IMSR_JAX:008462 |
| Mouse: B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J | JAX | Catalog # 006148 RRID:IMSR_JAX:006148 |
| Mouse: Pax7tm1(cre/Esr1*)Cklr (or Pax7CreER/CreER) | (Nishijo et al., 2009) | RRID:IMSR_NCIMR:01XBS |
| Mouse: B6.Cg-Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/J | JAX | Catalog # 007914 RRID:IMSR_JAX:007914 |
| Mouse: Oxct1LoxP | (Cotter et al., 2013) | N/A |
| Mouse: B6.Cg-Tg(Pax7ZsGreen)1Kyba/J | JAX | Catalog # 029549 RRID:IMSR_JAX:029549 |
| Mouse: NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ | JAX | Catalog # 005557 RRID:IMSR_JAX:005557 |
| Mouse: p53KQ | (Wang et al., 2016) | N/A |
| Oligonucleotides | ||
| Oxct1 Forward GCCCTGCATAAGGGGTGTG |
Harvard Primer Bank | N/A |
| Oxct1 Reverse GCAAGGTTGCACCATTAGGAAT |
Harvard Primer Bank | N/A |
| p21 Forward CCTGGTGATGTCCGACCTG |
Harvard Primer Bank | N/A |
| p21 Reverse CCATGAGCGCATCGCAATC |
Harvard Primer Bank | N/A |
| Recombinant DNA | ||
| Software and Algorithms | ||
| Improvision Volocity | Perkin Elmer | N/A |
| ZEN 2010 software | Carl Zeiss | N/A |
| Image Lab | Bio-Rad | N/A |
| Prism GraphPad | GraphPad Software | N/A |
| Python 3.6.4 | Python Software Foundation | N/A |
| Other | ||
| Ketogenic Diet | Bio-Serv | S3666 |
| Control Diet | Envigo Teklad | 2018 |