TABLE 1:
Distribution of socio-demographic characteristics, cancer-related factors, and traditional cardiovascular disease (CVD) risk factors in Head Neck Squamous Cell Carcinoma (HNSCC) patients diagnosed between 2012 and 2018, at baseline (at HNSCC diagnosis).
| Variables | No. of all HNSCC patients = 2262 |
No. of White patients = 1945 |
No. of Black patients = 317 |
p-value* |
|---|---|---|---|---|
| Age at HNSCC diagnosis (years) | ||||
| [Median (IQR)] | 61.0 (54.0-69.0) | 62.0 (55.0-69.0) | 60.0 (54.0-68.0) | 0.0767 |
| Gender | ||||
| Female | 581 (25.69) | 523 (26.89) | 58 (18.30) | 0.0012 |
| Male | 1681 (74.31) | 1422 (73.11) | 259 (81.70) | |
| Marital Status | ||||
| Married/ partner | 1256 (55.53) | 1143 (58.77) | 113 (35.65) | |
| Divorced/ separated/ widowed | 480 (21.22) | 416 (21.39) | 64 (20.19) | <0.0001 |
| Single | 473 (20.91) | 350 (17.99) | 123 (38.80) | |
| Unknown | 53 (2.34) | 36 (1.85) | 17 (5.36) | |
| Geographic location (rurality) | ||||
| Urban | 1390 (61.45) | 1166 (59.95) | 224 (70.66) | 0.0003 |
| Rural | 872 (38.55) | 779 (40.05) | 93 (29.34) | |
| HNSCC Site | ||||
| Oral cavity | 747 (33.02) | 669 (34.40) | 78 (24.61) | |
| Oropharynx | 727 (32.14) | 653 (33.57) | 74 (23.34) | <0.0001 |
| Larynx | 568 (25.11) | 450 (23.14) | 118 (37.22) | |
| Other | 220 (9.73) | 173 (8.89) | 47 (14.83) | |
| Clinical Stage at diagnosis | ||||
| Early (Stages 0/ I/ II) | 774 (34.22) | 694 (35.68) | 80 (25.24) | 0.0003 |
| Advanced (III/ IV) | 1133 (50.09) | 962 (49.46) | 171 (53.94) | |
| Other | 355 (15.69) | 289 (14.86) | 66 (20.82) | |
| Alcohol Use | ||||
| Current | 891 (39.39) | 761 (39.13) | 130 (41.01) | |
| Former | 176 (7.78) | 134 (6.89) | 42 (13.25) | 0.0004 |
| Never | 1128 (49.87) | 990 (50.90) | 138 (43.53) | |
| Unknown | 67 (2.96) | 60 (3.08) | 7 (2.21) | |
| Tobacco Use | ||||
| Current | 747 (33.02) | 627 (32.24) | 120 (37.85) | |
| Former | 841 (37.18) | 713 (36.66) | 128 (40.38) | 0.0039 |
| Never | 626 (27.67) | 565 (29.05) | 61 (19.24) | |
| Unknown | 48 (2.12) | 40 (2.06) | 8 (2.52) | |
| BMI Category | ||||
| Underweight/Normal | 896 (39.61) | 708 (36.40) | 188 (59.31) | |
| Overweight | 739 (32.67) | 664 (34.14) | 75 (23.66) | <0.0001 |
| Obese | 592 (26.17) | 549 (28.23) | 43 (13.56) | |
| Unknown | 36 (1.55) | 24 (1.23) | 11 (3.47) | |
| CVD clinical risk factors at baseline (at HNSCC diagnosis) | ||||
| Hypertension | 1293 (57.16) | 1119 (57.53) | 174 (54.89) | 0.3780 |
| Dyslipidemia | 694 (30.68) | 617 (31.72) | 77 (24.29) | 0.0078 |
| Diabetes | 361 (15.96) | 297 (15.27) | 64 (20.19) | 0.0266 |
Notes:
*
Bold= p -value ≤ 0.05; Abbreviation IQR = Interquartile range, BMI = Body mass index.