TABLE 2:
Associations of prevalence of ≥1 cardiovascular disease (CVD) clinical risk factors at baseline (at head and neck cancer diagnosis) with socio-demographic, behavioral, and cancer-related variables.
| Variables | ≥1 Prevalent CVD clinical risk factors (n=1441) vs none (n=639) |
|
|---|---|---|
| Unadjusted [OR (95% CI)]* |
Adjusted [OR (95% CI)]* |
|
| Age at HNSCC diagnosis (years) | ||
| 45 or less | Ref | Ref |
| 46 to <65 | 0.62 (0.41-0.95) | 0.61 (0.40-0.93) |
| 65 or above | 0.62 (0.40-0.95) | 0.62 (040-0.96) |
| Gender | ||
| Female | Ref | Ref |
| Male | 1.11 (0.89-1.37) | 1.04 (0.83-1.29) |
| Race | ||
| White | Ref | Ref |
| Black | 0.79 (0.61-1.03) | 0.71 (0.54-0.93) |
| Marital Status | ||
| Married/ partner | Ref | NA |
| Divorced/ separated/ widowed | 0.97 (0.77-1.23) | |
| Single | 0.95 (0.75-1.20) | |
| Geographic location (rurality) | ||
| Urban | Ref | Ref |
| Rural | 0.73 (0.60-0.88) | 0.70 (0.58-0.85) |
| HNSCC Site | ||
| Oral cavity | Ref | Ref |
| Oropharynx | 1.49 (1.19-1.88) | 1.50 (1.19-1.90) |
| Larynx | 1.63 (1.27-2.10) | 1.73 (1.34-2.24) |
| Other | 1.53 (1.09-2.17) | 1.64 (1.16-2.33) |
| Clinical Stage at diagnosis | ||
| Early (Stages 0/ I/ II) | Ref | NA |
| Advanced (III/ IV) | 1.05 (0.85-1.29) | |
| Other | 0.83 (0.63-1.11) | |
| Alcohol Use | ||
| Never | Ref | NA |
| Current | 1.11 (0.92-1.35) | |
| Former | 1.27 (0.89-1.83) | |
| Tobacco Use | ||
| Never | Ref | NA |
| Current | 1.07 (0.84-1.35) | |
| Former | 0.94 (0.74-1.18) | |
| BMI Category | ||
| Underweight/Normal | Ref | NA |
| Overweight | 1.22 (0.98-1.52) | |
| Obese | 1.22 (0.97-1.55) | |
Notes: Abbreviations *[OR (95% CI)] = Odds ratio (95% Confidence interval), HNSCC = head neck squamous cell carcinoma, BMI = Body mass index, NA= not applicable (as not included in adjusted model); Bold= p -value ≤ 0.05.