TABLE 2:
Associations of prevalence of ≥1 cardiovascular disease (CVD) clinical risk factors at baseline (at head and neck cancer diagnosis) with socio-demographic, behavioral, and cancer-related variables.
Variables | ≥1 Prevalent CVD clinical risk factors (n=1441) vs none (n=639) |
|
---|---|---|
Unadjusted [OR (95% CI)]* |
Adjusted [OR (95% CI)]* |
|
Age at HNSCC diagnosis (years) | ||
45 or less | Ref | Ref |
46 to <65 | 0.62 (0.41-0.95) | 0.61 (0.40-0.93) |
65 or above | 0.62 (0.40-0.95) | 0.62 (040-0.96) |
Gender | ||
Female | Ref | Ref |
Male | 1.11 (0.89-1.37) | 1.04 (0.83-1.29) |
Race | ||
White | Ref | Ref |
Black | 0.79 (0.61-1.03) | 0.71 (0.54-0.93) |
Marital Status | ||
Married/ partner | Ref | NA |
Divorced/ separated/ widowed | 0.97 (0.77-1.23) | |
Single | 0.95 (0.75-1.20) | |
Geographic location (rurality) | ||
Urban | Ref | Ref |
Rural | 0.73 (0.60-0.88) | 0.70 (0.58-0.85) |
HNSCC Site | ||
Oral cavity | Ref | Ref |
Oropharynx | 1.49 (1.19-1.88) | 1.50 (1.19-1.90) |
Larynx | 1.63 (1.27-2.10) | 1.73 (1.34-2.24) |
Other | 1.53 (1.09-2.17) | 1.64 (1.16-2.33) |
Clinical Stage at diagnosis | ||
Early (Stages 0/ I/ II) | Ref | NA |
Advanced (III/ IV) | 1.05 (0.85-1.29) | |
Other | 0.83 (0.63-1.11) | |
Alcohol Use | ||
Never | Ref | NA |
Current | 1.11 (0.92-1.35) | |
Former | 1.27 (0.89-1.83) | |
Tobacco Use | ||
Never | Ref | NA |
Current | 1.07 (0.84-1.35) | |
Former | 0.94 (0.74-1.18) | |
BMI Category | ||
Underweight/Normal | Ref | NA |
Overweight | 1.22 (0.98-1.52) | |
Obese | 1.22 (0.97-1.55) |
Notes: Abbreviations *[OR (95% CI)] = Odds ratio (95% Confidence interval), HNSCC = head neck squamous cell carcinoma, BMI = Body mass index, NA= not applicable (as not included in adjusted model); Bold= p -value ≤ 0.05.