TABLE 3:
Association of incident hypertension, dyslipidemia, and diabetes at one-year post head and neck cancer diagnosis with socio-demographic, behavioral, and cancer-related factors.
| Variables | Incident Hypertension at one- year [yes (n=660) vs no (n=238)] |
Incident dyslipidemia at one-year [yes (n=251) vs no (n=1186)] |
Incident diabetes at one-year [yes (n=153) vs no (n=1589)] |
|||
|---|---|---|---|---|---|---|
| Unadjusted* [RR (95%CI)] |
Adjusted* [RR (95%CI)] |
Unadjusted* [RR (95%CI)] |
Adjusted* [RR (95%CI)] |
Unadjusted* [RR (95%CI)] |
Adjusted* [RR (95%CI)] |
|
| Age at HNSCC diagnosis (years) | ||||||
| 45 or less | Ref | Ref | Ref | Ref | Ref | Ref |
| 46 to <65 | 1.44 (1.03-2.01) | 1.39 (1.01-1.93) | 5.11 (1.65-15.85) | 5.80 (1.85-18.11) | 2.83 (0.90-8.88) | 3.45 (1.10-10.87) |
| 65 or above | 1.65 (1.18-2.31) | 1.52 (1.10-2.10) | 12.26 (3.97-37.83) | 12.64 (4.07-39.28) | 5.30 (1.70-16.51) | 5.92 (1.87-18.76) |
| Gender | ||||||
| Female | Ref | Ref | Ref | Ref | Ref | Ref |
| Male | 0.91 (0.84-0.98) | 0.97 (0.89-1.06) | 0.90 (0.70-1.16) | 1.07 (0.83-1.38) | 0.83 (0.59-1.15) | 1.02 (0.74-1.39) |
| Race | ||||||
| White | Ref | Ref | Ref | Ref | Ref | Ref |
| Black | 1.02 (0.91-1.14) | 1.11 (0.99-1.24) | 0.53 (0.35-0.81) | 0.73 (0.50-1.08) | 0.80 (0.49-1.32) | 1.21 (0.74-1.96) |
| Marital Status | ||||||
| Married/ with partner | Ref | Ref | Ref | Ref | Ref | Ref |
| Divorced/ separated/ widowed | 1.09 (1.00-1.19) | 1.06 (0.97-1.15) | 0.94 (0.72-1.24) | 0.93 (0.71-1.29) | 0.89 (0.61-1.29) | 0.91 (0.64-1.30) |
| Single | 0.89 (0.80-1.00) | 0.92 (0.82-1.02) | 0.46 (0.32-0.66) | 0.57 (0.41-0.84) | 0.52 (0.32-0.82) | 0.74 (0.46-1.18) |
| Geographic location (rurality) | ||||||
| Urban | Ref | NA | Ref | NA | Ref | Ref |
| Rural | 1.01 (0.93-1.09) | 1.01 (0.80-1.27) | 1.67 (1.23-2.26) | 1.63 (1.21-2.19) | ||
| HNSCC Site | ||||||
| Oral cavity | Ref | Ref | Ref | Ref | Ref | Ref |
| Oropharynx | 0.77 (0.70-0.85) | 0.86 (0.78-0.96) | 0.67 (0.51-0.87) | 0.77 (0.57-1.03) | 0.58 (0.40-0.84) | 0.60 (0.40-0.89) |
| Larynx | 0.74 (0.66-0.83) | 0.80 (0.71-0.90) | 0.52 (0.37-0.72) | 0.63 (0.45-0.88) | 0.49 (0.32-0.77) | 0.57 (0.37-0.90) |
| Other | 0.90 (0.79-1.02) | 0.94 (0.83-1.06) | 0.61 (0.39-0.96) | 0.68 (0.44-1.05) | 0.97 (0.60-1.56) | 0.90 (0.56-1.44) |
| Clinical Stage at diagnosis | ||||||
| Early (Stages 0/ I/ II) | Ref | NA | Ref | Ref | Ref | NA |
| Advanced (III/ IV) | 0.97 (0.88-1.06) | 0.69 (0.51-0.88) | 0.92 (0.71-1.18) | 0.99 (0.70-1.40) | ||
| Other | 1.05 (0.94-1.16) | 0.79 (0.56-1.11) | 0.86 (0.63-1.19) | 1.27 (0.82-1.95) | ||
| HNSCC treatment | ||||||
| Surgery only | Ref | Ref | Ref | Ref | Ref | Ref |
| Radiation | 0.81 (0.73-0.89) | 0.86 (0.78-0.95) | 0.69 (0.51-0.94) | 0.86 (0.63-1.19) | 0.67 (0.44-1.03) | 0.90 (0.56-1.44) |
| Chemotherapy | 0.73 (0.56-0.95) | 0.79 (0.61-1.03) | 0.33 (0.13-0.87) | 0.64 (0.25-1.62) | 0.86 (0.39-1.88) | 1.30 (0.59-1.36) |
| Chemoradiation | 0.73 (0.64-0.83) | 0.81 (0.70-0.93) | 0.62 (0.44-0.88) | 0.95 (0.63-1.42) | 0.78 (0.51-1.19) | 1.23 (0.76-1.98) |
| Other | 0.67 (0.59-0.76) | 0.72 (0.63-0.82) | 0.52 (0.37-0.72) | 0.70 (0.50-0.97) | 0.35 (0.21-0.59) | 0.45 (0.26-0.75) |
| Alcohol Use | ||||||
| Never | Ref | Ref | Ref | Ref | Ref | |
| Current | 1.03 (0.95-1.12) | NA | 0.75 (0.59-0.96) | 0.81 (0.63-1.02) | 0.51 (0.36-0.71) | 0.60 (0.42-0.84) |
| Former | 0.99 (0.84-1.16) | 0.91 (0.60-1.38) | 1.09 (0.73-1.63) | 0.55 (0.28-1.05) | 0.61 (0.33-1.16) | |
| Tobacco Use | ||||||
| Never | Ref | Ref | Ref | Ref | Ref | Ref |
| Current | 0.97 (0.87-1.08) | 1.08 (0.97-1.20) | 0.66 (0.49-0.89) | 1.13 (0.83-1.54) | 0.49 (0.33-0.75) | 0.86 (0.56-1.32) |
| Former | 1.08 (0.98-1.18) | 1.17 (1.06-1.28) | 0.99 (0.76-1.29) | 1.22 (0.93-1.58) | 0.86 (0.61-1.21) | 1.06 (0.75-1.48) |
| BMI Category | ||||||
| Underweight/Normal | Ref | Ref | Ref | Ref | Ref | Ref |
| Overweight | 1.03 (0.93-1.13) | 1.02 (0.94-1.12) | 1.73 (1.30-2.29) | 1.59 (1.20-2.11) | 2.04 (1.34-3.08) | 1.98 (1.31-2.98) |
| Obese | 1.12 (1.02-1.23) | 1.13 (1.03-1.24) | 2.05 (1.54-2.73) | 2.06 (1.55-2.73) | 3.28 (2.20-4.88) | 3.18 (2.13-4.76) |
Notes: Abbreviations *[RR (95%CI)]=Risk ratio(95% CI), HNSCC = head neck squamous cell carcinoma, BMI = Body mass index, NA= not applicable (as not included in adjusted model); Bold= p -value ≤ 0.05.