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. Author manuscript; available in PMC: 2023 Jun 2.
Published in final edited form as: Cell Stem Cell. 2022 May 3;29(6):905–917.e6. doi: 10.1016/j.stem.2022.04.006

Figure 3.

Figure 3.

Differential gene analysis on lung tumor tissue vs. derived MOS. (A) Pseudo-bulk differential expression analysis comparing lung cancer primary tissue and derived MOS datasets (n=3). Genes with absolute log-fold change > 1.5 are labeled in red. (B) Volcano plots of differentially expressed genes from fibroblasts, lymphoid cells, myeloid cells, and tumor cells from lung tumor samples. (C) Expression of cancer-associated marker genes CD274 (PD-L1), PDCD1 (PD-1), and TGFB1 (TGF-beta) plotted as UMAPs. Cells are plotted on separate UMAPs depending on source: primary tissue (left) or MOS (right). (D) Top five identified conserved markers for each cell type and labeled by cell source.