Table 5.
Acute toxicity (LD50) results from intraperitioneal administration
| Cocktails | No of mice | Dose (mg/kg) | Weakness/reduced activity | Clogging together | Day 0 mortality | % Mortality | LD50 (mg/kg) | Day 7 Mortality | Day 14 Mortality |
|---|---|---|---|---|---|---|---|---|---|
| Lorke’s phase 1 | |||||||||
| CtA | 3 | 10 | No | No | 0 | 0 | 0 | 0 | |
| 3 | 100 | No | No | 0 | 0 | 0 | 0 | ||
| 3 | 1000 | Yes | No | 1 | 33% | 2 | - | ||
| CtB | 3 | 10 | No | No | 0 | 0 | 0 | 0 | |
| 3 | 100 | No | No | 0 | 0 | 0 | 0 | ||
| 3 | 1000 | Yes | No | 3 | 100 | ||||
| Lorke’s phase 2 | |||||||||
| CtA | 1 | 1600 | Yes | Yes | 1 | 100 | CtA = 316.23 | ||
| 1 | 2900 | Yes | Yes | 1 | 100 | ||||
| 1 | 5000 | Yes | Yes | 1 | 100 | ||||
| CtB | 1 | 1600 | ND | ||||||
| 1 | 2900 | ND | |||||||
| 1 | 5000 | ND | |||||||