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. 2022 May 27;50(10):5713–5725. doi: 10.1093/nar/gkac410

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Model of influenza virus RNA genome replication. (i) ANP32 mediates the recruitment of a free influenza virus polymerase (encapsidating polymerase, FluPol_E) to the polymerase resident in a vRNP (replicating polymerase, FluPol_R) through its N-terminal LRR domain (red oval), leading to polymerase dimerization. (ii) FluPol_R initiates cRNA synthesis and the 5′ end of the nascent cRNA (orange) is captured by FluPol_E. The flexible C-terminal LCAR of ANP32 (red line) recruits free NP molecules and increases local NP density. (iii) ANP32 LCAR facilitates the transfer of NP to nascent cRNA. NP dissociates from the LCAR and binds to cRNA due to its higher affinity to RNA. (iv) cRNA is assembled into a mature cRNP before being released from the template vRNP complex.