Figure 1.

Organisational Flowchart fossr the Purification and Characterisation of Sense and Antisense LincRNA-p21 AluSx1 RNA. The determination of LincRNA three-dimensional, low-resolution structures overlaid by high-resolution, atomistic models was conducted in three phases: RNA preparation and biophysical studies to determine sample homogeneity and sample properties; low-resolution structure determination by SAXS; and high-resolution modelling using SimRNA, with constraints imposed by HYDROPRO. All methods are further described below.