TABLE 4.

Cox proportional hazards models for prognosis in diabetic patients.

	Univariate		Multivariate
	HR (95% CI)	P-value	HR (95% CI)	P-value
MACE
Big ET-1*	1.85 (1.26–2.72)	0.002	2.05 (1.36–3.09)	0.001
Big ET-1 tertile 1	Reference	–	Reference	–
Big ET-1 tertile 2	1.35 (0.59–3.09)	0.477	1.24 (0.51–3.05)	0.634
Big ET-1 tertile 3	2.32 (1.09–4.92)	0.029	2.60 (1.16–5.81)	0.02
Secondary endpoints
Big ET-1*	1.77 (1.19–2.63)	0.005	1.98 (1.29–3.03)	0.002
Big ET-1 tertile 1	Reference	–	Reference	–
Big ET-1 tertile 2	1.06 (0.46–2.43)	0.893	0.97 (0.40–2.37)	0.948
Big ET-1 tertile 3	1.93 (0.93–4.04)	0.079	2.00 (0.91–4.41)	0.084

*Big endothelin-1 (ET-1) was natural log-transformed. Major adverse cardiovascular events (MACE) model adjusted for age, sex, angulated lesion, history of coronary artery bypass grafting [CABG], low-density lipoprotein cholesterol [LDL-c], reference vessel diameter, thyroid disease. Secondary end points model adjusted for age, sex, angulated lesion, history of CABG, early ISR, and non-ISR lesion intervention.