TABLE 6.

C-statistics of traditional risk factors and big ET-1 in patients with diabetes.

	MACE			Secondary end points
	C-statistic (95% CI)	ΔC-statistic	P-value	C-statistic (95% CI)	ΔC-statistic	P-value
Model 1*	0.60 (0.53–0.68)	Reference	–	0.63 (0.56–0.71)	Reference	–
Model 2*	0.64 (0.56–0.72)	0.033	0.03	0.67 (0.59–0.75)	0.035	0.02
Model 3*	0.68 (0.60–0.75)	Reference	–	0.66 (0.57–0.74)	Reference	–
Model 4*	0.68 (0.60–0.76)	0.005	0.32	0.66 (0.57–0.74)	0.002	0.46

*Model 1: traditional risk factors [age, sex, BMI, smoking, hypertension, hyperlipidemia, stroke or transient ischemic attack (TIA), and left ventricular ejection fraction (LVEF)]; Model 2: traditional risk factors + big endothelin-1 (ET-1); Model 3: traditional and angiographic risk factors [major adverse cardiovascular events (MACE) model adjusted for age, sex, LVEF, in-stent restenosis (ISR) duration, hypertension, DES intervention, total cholesterol (TC), and diameter stenosis rate]. Secondary end points [model adjusted for age, sex, high-density lipoprotein cholesterol (HDL-c), TC, reference vessel diameter, target lesion length, and diameter stenosis rate]; Model 4: traditional and angiographic risk factors + big ET-1.