Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jan 21;50(10):5443–5466. doi: 10.1093/nar/gkac018

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 1. — Controlling backbone chemistry and stereochemistry for synthesis of exon-skipping oligonucleotides. (A) Images of backbone chemistry and stereochemistry used in this work. (B) The L chiral auxiliary leads to Rp configuration of a PN linkage and Sp configuration of a PS linkage with identical geometry. (C) Crystal structures for the PN-fCfC dimers in the Rp (left) and Sp (right) configurations. (D) Ratio of Rp to Sp linkages from reverse-phase (RP)-UPLC analysis post-dimer synthesis illustrating diastereoselectivity.