Table 2.

Association signal overlap between the 2df joint test (accounting for interactions) and previous GWAS of marginal genetic effect.

Phenotype	Overall			CHARGE only, per exposure
	External GWAS only	Both	CHARGE only	Current drinking	Drinking habits	Current smoking	Ever smoking
HDL	70	83	21	18	17	11	11
LDL	60	63	30	25	17	6	6
TG	91	57	15	9	11	6	5
SBP	33	37	35	21	6	27	28
DBP	47	46	26	16	4	22	17
All	301	286	127	89	55	72	67

HDL high-density lipoprotein, LDL low-density lipoprotein, TG triglycerides, SBP systolic blood pressure, DBP diastolic blood pressure, 1df 1 degree of freedom interaction test, 2df 2 degrees of freedom joint test, disc discovery stage, rep replication stage.