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. 2022 May 26;13:881684. doi: 10.3389/fendo.2022.881684

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Copyright © 2022 Chen, Jia, Liu, Cao, Zhou and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of adipokine expression and its role in PCOS. The solid dots of different colors represents the distribution of adipokines, with the corresponding Y as their receptors . represents for promotion and inhibition respectively. As shown in the figure, leptin and adiponectin regulates hypothalamic secretion of GnRH. Leptin, together with Adiponectin and Chemerin regulates progesterone production. Resistin is related to testosterone production without clear mechanism. Chemerin and Omentin are associated with inflammation. Chemerin, Apelin, Leptin, Vaspin, Omentin play a role in regulating IR. In addition, Adiponectin is closely related to ovulation and Chemerin is involved in the formation of PCOM.GnRH, gonadotropin-releasing hormone; Gn, gonadotropin; LH, luteinizing hormone; P, proges-terone; T, testosterone; E2, Estrodiol; PCOM, polycystic ovary morphology; PGE, prostaglandin E; MAPK, mitogen-activated protein kinase; COX2, cyclooxygenase-2; CYP17A1, cytochrome P45017A1; CYPI1A1, cytochrome P45011A1; IGF-1, insulin-like growth factor 1; IR, insulin resistance; IRS, Insulin receptor substrate; AKT, protein kinase B; INF- y , Interferon- y ; 3 8 -HSD, 3 6 -hydroxysteroid dehydrogenase; GLUT4, glucose transporter4.

Inline graphic — Schematic representation of adipokine expression and its role in PCOS. The solid dots of different colors represents the distribution of adipokines, with the corresponding Y as their receptors . represents for promotion and inhibition respectively. As shown in the figure, leptin and adiponectin regulates hypothalamic secretion of GnRH. Leptin, together with Adiponectin and Chemerin regulates progesterone production. Resistin is related to testosterone production without clear mechanism. Chemerin and Omentin are associated with inflammation. Chemerin, Apelin, Leptin, Vaspin, Omentin play a role in regulating IR. In addition, Adiponectin is closely related to ovulation and Chemerin is involved in the formation of PCOM.GnRH, gonadotropin-releasing hormone; Gn, gonadotropin; LH, luteinizing hormone; P, proges-terone; T, testosterone; E2, Estrodiol; PCOM, polycystic ovary morphology; PGE, prostaglandin E; MAPK, mitogen-activated protein kinase; COX2, cyclooxygenase-2; CYP17A1, cytochrome P45017A1; CYPI1A1, cytochrome P45011A1; IGF-1, insulin-like growth factor 1; IR, insulin resistance; IRS, Insulin receptor substrate; AKT, protein kinase B; INF- y , Interferon- y ; 3 8 -HSD, 3 6 -hydroxysteroid dehydrogenase; GLUT4, glucose transporter4.