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Autophagy is involved in several steps of skeletal muscle regeneration. (i) Degradation of necrotic myofibres and release of secretory factors; (ii) quiescent maintenance, activation, proliferation and differentiation of skeletal muscle stem cells; (iii) mitochondrial network remodelling mediated by mitophagy; (iv) differentiation and polarization of macrophages; (v) endothelial cell mediated angiogenesis and secretory factor release.
