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. 2022 May 26;13:872387. doi: 10.3389/fimmu.2022.872387

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Copyright © 2022 Zhao, Yin, Peng, Cai, He, Shi, Peng, Tu, Li, Li, Tao, Peng, Wang and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of DEGs between pGGO and adjacent normal tissue and NMF clustering. (A) Heatmap of the DEGs (|log FC|> 1, FDR P < 0.05); (B) Volcano map of the DEGs (|log FC|> 1, FDR P < 0.05); (C) KEGG pathway enrichment analysis of the DEGs; (D, E) NMF clustering of patients with Stage I–II LUAD in the TCGA-LUAD cohort (D shows the NMF rank survey and E shows a heatmap of the consensus matrix; the best cluster number was chosen as the coexistence correlation coefficient K value = 2); (F, G) Kaplan–Meier survival curves for the NMF subgroups (F shows OS and G shows PFS). DEGs, differentially expressed genes; GGO, ground-glass opacity; KEGG: Kyoto Encyclopedia of Genes and Genomes; NMF, non-negative matrix factorization; LUAD, lung adenocarcinoma; PFS, progression-free survival; OS, overall survival.