Figure 6.

HUC-MSCs regulate immune cell balance. (a) Transplant of HUC-MSCs downregulated activated macrophage in the colon mucosa. With the treatment with DSS, the activated macrophages in the colon mucosa were significantly increased, whereas therapy with HUC-MSCs, the percentage of activated macrophages was decreased greatly. (b) HUC-MSCs have no significant effect on the proportion of B cells in DSS-induced colitis mice. (c, d) Transplant of HUC-MSCs decreased Th1 and Th2 in DSS-induced colitis mice. (e, f) Transplant of HUC-MSCs decreased Th17 while increased Treg in DSS-induced colitis mice. (g–j) The influence of HUC-MSCs on differentiation and secretion of macrophages. Error bars: mean ± SD. ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.005.