Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 7;219(7):e20220047. doi: 10.1084/jem.20220047

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Elias et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Figure 1. — Features of CXCR4⁺ BM Treg cells. (A) Distribution of CXCR4⁺ Treg cells in different tissues. mLN, mesenteric lymph nodes; PB, peripheral blood; pLN, peripheral lymph nodes; PP, Peyer’s patches. (B) Analysis of intra- (IV) and extravascular Treg cells in Foxp3^DTR-EGFP mice labeled with CD45-BV570 for 3 min in the indicated tissues. (C) Analysis of CD4conv and Treg cells in CD45.1⁺ and CD45.2⁺ Foxp3^DTR-EGFP parabionts 2 wk after surgery. LI, large intestine. (D) t-Distributed stochastic neighbor embedding (t-SNE) visualization of scRNA-seq of spleen and BM Treg cells. Clustering analysis (left) and select gene distribution (right). (E) Distribution of BM and spleen Treg cells among scRNA-seq clusters (left) and CXCR4⁺ Treg numbers (right). The data from one representative experiment of two independent experiments are shown in A–C. *, P < 0.05; ***, P < 0.001; ****, P < 0.001; ANOVA with multiple comparisons (Tukey post-hoc test; B, C).