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. 2022 Jun 9;12:9510. doi: 10.1038/s41598-022-12751-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma levels of MG, glutathione, Glo1 SSAO, TNF-α, IL-1β and CRP in uninfected control and ICU COVID-19 patients. (A) MG levels (detected as its surrogate, HSA-MG) were significantly higher in ICU COVID-19 patients compared to uninfected controls. (B) Glutathione levels were significantly lower in ICU COVID-19 patients compared to uninfected controls. (C) Glo1 levels in ICU COVID-19 patients were not significantly different from uninfected controls. (D–G) SSAO, TNF-α, IL-1β and CRP levels were significantly higher in ICU COVID-19 patients compared to uninfected controls, respectively. Data shown are for each patient with mean ± S.E.M from n = 30 uninfected controls (26.6% females) and n = 65 ICU COVID-19 patients (29.3% females). Statistical significances are shown above sets of data points on the graphs.