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. 2022 Jun 9;12:9510. doi: 10.1038/s41598-022-12751-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma levels of neutrophils, lymphocytes, monocytes, basophils and eosinophils in uninfected non-DM individuals and ICU COVID-19 patients that survived and died. (A) Neutrophils levels in blood from ICU COVID-19 patients that survived and died were significantly higher than that in uninfected controls. Neutrophils levels in blood from ICU COVID-19 that died were also significantly higher than ICU COVID-19 patients that survived. (B) Lymphocytes in blood from ICU COVID-19 patients that survived and died were significantly lower than that in uninfected controls. However, there were no significant difference in blood levels of lymphocytes in ICU COVID-19 patients that survived and died. (C) Monocytes in blood from ICU COVID-19 patients that survived were not significantly different from that in uninfected controls. However, monocytes levels in blood from ICU COVID-19 patients that died were significantly higher than that in uninfected controls and ICU COVID-19 patients that survived. (D) Basophils levels in blood from ICU COVID-19 patients that survived but not died were significantly higher than that in uninfected controls. There was no significant difference in blood basophils levels between ICU COVID-19 patients that died and survived. (E) Eosinophils levels in blood from ICU COVID-19 patients that survived and died were significantly higher than that in uninfected controls. However, there were no significant difference in blood levels of eosinophils in ICU COVID-19 patients that survived and died. Data shown are mean ± S.E.M from n = 30 in uninfected controls (26.6% females), n = 33 died (42.4% females) and n = 32 in survived (37.5% females). Statistical significance levels are shown above data points on each graph.