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. 2022 Jun 9;12:9510. doi: 10.1038/s41598-022-12751-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Blood levels of neutrophils, lymphocytes, and monocytes in ICU COVID-19 patients without diabetes mellitus (non-DM) and with diabetes (DM) and separated into those that survived and those that died. (A) Neutrophils levels in blood from non-DM and DM ICU COVID-19 patients were significantly higher than uninfected non-DM individuals. There was also a significant difference in blood neutrophils levels between non-DM and DM ICU COVID-19 patients. (B) No significant differences in neutrophils levels in blood from non-DM ICU COVID-19 patients that died and survived. However, there was a significant difference in blood neutrophils levels between DM ICU COVID-19 patients that survived and died. (C) Lymphocytes levels in blood from non-DM and DM ICU-COVID-19 patients were significantly higher than uninfected non-DM individuals. There was not a significant difference in lymphocytes levels in blood from non-DM and DM ICU COVID-19 patients. (D) No significant differences in blood levels of lymphocytes in non-DM and DM ICU COVID-19 patients that died and survived. (E) Monocytes levels in blood from non-DM and DM ICU COVID-19 patients were not significantly higher than uninfected non-DM individuals. Monocytes levels in blood from DM ICU COVID-19 were also not significantly higher than of non-DM ICU-COVID-19 patients. (F) Significant difference in blood levels of monocytes in non-DM and DM ICU COVID-19 patients that died and survived. Data shown in (A, C, E) are mean ± S.E.M from n = 30 in uninfected non-DM individuals (26.6% females), n = 34 in non-DM (33.3% females) and n = 31 in DM (25.8% females) group. Data shown in (B, D, F) are mean ± S.E.M from n = 30 in uninfected non-DM individuals (26.6% females), n = 18 in non-DM survived (44.4% females), n = 16 in non-DM died (30.7% females), n = 14 DM in survived (28.6% females), and n = 17 in DM died (37.5% females) groups. Statistical significances are shown above data points on each graph.