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. Author manuscript; available in PMC: 2022 Sep 29.
Published in final edited form as: AAPS PharmSciTech. 2021 Sep 29;22(7):240. doi: 10.1208/s12249-021-02108-5

Table 1:

The effect of surfactants on average particle size and PDI of blank NLC.

Surfactants (1.5 % w/v) HLB Particle size (nm) PDI

Poloxamer® 188 29 222 0.15
Sodium cholate 18 266 0.19
Solutol® HS 15 15 265 0.19
Tween® 80 15 188 0.18
Lauroglycol™ FCC 4 427 0.35
Span® 80 4.3 412 0.4
Poloxamer® 188: Solutol® HS 15=1:1 22 289 0.2
Tween® 80: Solutol® HS 15=1:1 15 231 0.21
Tween® 80: Poloxamer® 188=1:1 22 202 0.15
Tween® 80: Span® 80=4:1 12.9 180 0.21
Tween® 80: Poloxamer® 188: Span® 80=1:1:1 16.1 270 0.22
Tween® 80: Solutol® HS 15: Span® 80=1:1:1 11.4 311 0.21
Poloxamer® 188: Solutol® HS 15: Span® 80=1:1:1 16.1 356 0.24