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. 2022 May 19;24(1):218. doi: 10.3892/ol.2022.13339

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Copyright: © Khan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — In silico interaction of EGCG, SAM, SAH, 5-aza-dc and vitamin C with DNMTs. (A) Predicted binding sites for SAM (yellow) and EGCG (green) in DNMT1_A chain. (B) Predicted binding sites for 5-aza-dc (orange), SAM (blue) and EGCG (green) in DNMT1_B chain. (C) Predicted binding sites for SAM (blue), SAH (pink), EGCG (green) and vitamin C (white) in DNMT3a. (D) Predicted binding sites for SAM (blue), SAH (pink), EGCG (green) and 5-aza-dc (orange) in DNMT3b. DNMT, DNA methyltransferase; 5-aza-dc, 5-Azacytadine; VC, vitamin C; EGCG, Epigallocatechin gallate; SAM, S-adenosyl methionine; SAH, S-adenosyl homocysteine.