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EGCG effect on IFI16 gene promoter. The proposed model showed IFI16 gene promoter is methylated by DNMT-mediated catalysis of methyl group incorporation. EGCG treatment can block the DNMT activity and in turn decrease methylation level in IFI16 gene promoter, leading to transcriptional activation of IFI16 gene. IFI, IFN-induced protein; EGCG, Epigallocatechin gallate; DNMT, DNA methyltransferase.
