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. 2022 May 17;24(1):212. doi: 10.3892/ol.2022.13333

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Copyright: © Yin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Analysis of CD8+ TILs and CD66b+ TANs in the invasive margin of CRC. (A) The ‘invasive margin’ is defined as the region centered on the border separating the host tissue from the malignant nets, with an extent of 1 mm (40×). (B) Representative images of high-density and low-density CD8+ TILs and CD66b+ TANs in the invasive margin of CRC (200×). (C) CD8+ TILs and CD66b+ TANs counts in the invasive margins of all patients (n=103). (D) Correlation between CD8+ TILs and CD66b+ TANs in CRC. Correlation analysis was performed with Spearman's rank correlation coefficient. TILs, tumor-infiltrating lymphocytes; TANs, tumor-associated neutrophils; CRC, colorectal cancer.