Table II.
Association between the infiltration of immune cells and clinicopathological characteristics of patients with CRC.
| Variables | CD8+ number/HPF mean ± SD | P-value | CD66b+ number/HPF [median (IQR)] | P-value |
|---|---|---|---|---|
| Agea | 0.10 | 0.85 | ||
| Low (<71 years) | 85.9±31.6 | 68.7 (17.9-115.2) | ||
| High (≥71 years) | 81.1±27.9 | 60.8 (21.0-117.5) | ||
| Gender | 0.98 | 0.96 | ||
| Male | 83.5±31.6 | 60.8 (20.7-117.0) | ||
| Female | 83.4±26.9 | 70.0 (19.8-116.5) | ||
| Location | 0.54 | 0.59 | ||
| Colon | 81.9±29.6 | 65.0 (20.7-108.3) | ||
| Rectum | 85.6±30.1 | 67.5 (23.4-127.8) | ||
| Differentiation | 0.15 | 0.22 | ||
| Differentiated | 82.3±29.9 | 67.7 (20.7-121.0) | ||
| Undifferentiated | 97.3±25.0 | 45.8 (15.8-74.1) | ||
| Pathological T category | 0.78 | 0.52 | ||
| pT1/2 | 84.4±31.3 | 67.7 (37.5-106.9) | ||
| pT3/4 | 82.8±28.7 | 60.8 (11.3-129.2) | ||
| Vessel invasion | 0.32 | 0.70 | ||
| Absent | 87.0±34.2 | 65.0 (12.5-115.0) | ||
| Present | 81.1±26.2 | 62.7 (27.5-118.0) | ||
| Lymph node metastasis | 0.73 | 0.01b | ||
| Absent | 82.9±29.6 | 34.0 (9.0-82.7) | ||
| Present | 84.8±30.1 | 79.5 (36.9-126.2) | ||
| UICC stage classification | 0.96 | 0.05b,c | ||
| Stage I | 82.7±31.6 | 73.5 (39.0-109.3) | ||
| Stage II | 83.1±27.4 | 84.5 (15.3-146.3) | ||
| Stage III | 84.8±30.4 | 34.0 (9.0-82.7) | ||
| MSI | 0.40 | 0.75 | ||
| MSI | 92.1±31.4 | 72.7 (55.8-101.7) | ||
| MSS | 82.8±29.6 | 60.8 (19.6-118) | ||
| KRAS | 0.03b | 0.68 | ||
| Mutation | 76.8±31.6 | 69.8 (22.0-110.2) | ||
| Wild | 89.6±26.7 | 55.1 (13.3-120.8) | ||
| BRAF | 0.37 | 0.16 | ||
| Mutation | 94.0±14.0 | 40.3 (7.9-79.1) | ||
| Wild | 82.8±30.3 | 67.7 (20.8-119.5) |
a
Median age at surgery was 71 years in this cohort.
b
P<0.05.
c
Stage I vs. III, P=0.04. CRC, colorectal cancer; MSI, microsatellite instability; MSS, microsatellite stability; UICC, Union for International Cancer Control; SD, standard deviation.