Table III.
Multivariate analysis for OS of patients with stages I–III CRC.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
|
|
|
|||||
| Variables | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Gender (Male) | 1.39 | 0.55-3.95 | 0.49 | |||
| Age (≥71 years)a | 1.52 | 0.63-3.91 | 0.36 | |||
| Location (Rectum) | 1.09 | 0.44-2.65 | 0.84 | |||
| Differentiation (Undifferentiated) | 4.22 | 1.20-11.7 | 0.03c | 2.90 | 0.82-8.16 | 0.09 |
| Pathological T category (T3/T4) | 1.84 | 0.74-5.20 | 0.19 | 1.56 | 0.61-4.49 | 0.36 |
| Vessel invasion (Present) | 1.21 | 0.49-3.22 | 0.69 | |||
| Lymph node metastasis (Present) | 1.58 | 0.62-3.85 | 0.32 | |||
| MSI (MSI-L/MSS) | 1.49 | 0.31-26.8 | 0.68 | |||
| KRAS (Wild) | 1.73 | 0.71-4.63 | 0.23 | |||
| BRAF (Wild) | 1.11 | 0.23-19.9 | 0.92 | |||
| CD66b+ (Low) | 8.82 | 2.51-55.9 | 0.0002c | |||
| CD8+ (Low) | 3.15 | 1.14-11.1 | 0.04c | |||
| CD8+CD66b+ (Low-Low)b | 4.41 | 1.75-12.6 | 0.002c | 3.80 | 1.48-11.0 | 0.005c |
a
The median age at surgery was 71 years in this cohort;
b
The cutoff value determined by ROC curve analysis for survival;
c
P<0.05. CRC, colorectal cancer; OS, overall survival; HR, hazard ratio; CI, confidence interval.