Table IV.

Multivariate analysis of DFS of patients with stage I–III CRC.

	Univariate			Multivariate
Variables	HR	95% CI	P-value	HR	95%CI	P-value
Gender (Male)	1.54	0.73-3.53	0.26
Age (≥71 years)a	0.83	0.41-1.70	0.60
Location (Rectum)	1.00	0.48-2.04	0.99
Differentiation (Undifferentiated)	2.17	0.64-5.57	0.19	1.58	0.46-4.21	0.43
Pathological T category (T3/T4)	2.48	1.15-5.92	0.02c	1.87	0.82-4.71	0.14
Vessel invasion (Present)	1.64	0.78-3.78	0.19	1.32	0.59-3.17	0.51
Lymph node metastasis (Present)	2.18	1.06-4.44	0.04c	1.22	0.54-2.79	0.62
MSI (MSI-L/MSS)	2.51	0.54-44.6	0.29
KRAS (Wild)	1.19	0.59-2.46	0.63
BRAF (Wild)	2.02	0.43-36.0	0.44
CD66b+ (Low)	3.12	1.41-7.88	0.004
CD8+ (Low)	3.35	1.46-9.06	0.003
CD8+CD66b+ (Low-Low)b	3.04	1.48-6.47	0.002c	2.52	1.18-5.58	0.02c

^aThe median age at surgery was 71 years in this cohort;

^bThe cutoff value was determined using ROC curve analysis for survival;

^cP<0.05. CRC, colorectal cancer; DFS, disease-free survival; HR, hazard ratio; CI, confidence interval.