Table 3.
Distribution of selected cases of retinal vascular occlusion in analysis cohort by unilateral/bilateral onset and subtype together with estimates of the precision of differences and associations.
| Number of cases with specified laterality | % Unilateral onseta | % Bilateral onset | % Unilateral onset – % bilateral onset | 99% CI of % unilateral onset – % bilateral onsetb | ORc | 99% CI of ORc | ||
|---|---|---|---|---|---|---|---|---|
| Entire set of IRIS Registry diagnoses | 138,229,879 | 32.3 | 67.7 | −35.4 | ||||
| Retinal vascular occlusion | 798,089 | 90.5 | 9.5 | 81 | (80.84, 81.08) | 19.92 | (19.77, 20.16) | |
| RAO | 162,765 | 91.2 | 8.8 | 82.3 | (82.08, 82.59) | 21.62 | (21.24, 22.22) | |
| TRAO | 19,013 | 72.5 | 27.5 | 45.1 | (43.91, 46.27) | 5.54 | (5.30, 5.76) | |
| PRAO | 34,534 | 94.1 | 5.9 | 88.3 | (87.82, 88.75) | 33.67 | (31.52, 35.45) | |
| BRAO | 61,637 | 93.2 | 6.8 | 86.5 | (86.08, 86.82) | 28.84 | (27.57, 29.94) | |
| CRAO | 47,581 | 93.8 | 6.2 | 87.6 | (87.16, 87.97) | 31.59 | (30.19, 33.3) | |
| RVO | 635,324 | 90.3 | 9.7 | 80.6 | (80.48, 80.75) | 19.52 | (19.30, 19.73) | |
| VE | 12,211 | 39.3 | 60.7 | −21.5 | (−23.08, −19.85) | 1.35 | (1.29, 1.42) | |
| BRVO | 380,798 | 91.7 | 8.3 | 83.4 | (83.21, 83.54) | 23.11 | (22.81, 23.51) | |
| CRVO | 242,315 | 90.7 | 9.3 | 81.4 | (81.20, 81.63) | 20.45 | (20.08, 20.81) | |
H0 hypothesis states that the proportion of unilateral onset cases in each subtype is 32.3% (the proportion of that in the entire set of IRIS Registry diagnoses). Two-tailed p<0.0001 for all subtypes using the binomial test.
H0 hypothesis states that the proportions of unilateral and bilateral onset cases in each subtype are the same. Two-tailed p<0.0001 for all subtypes using the Z test.
The OR and 99% CI of OR when setting the population of the entire IRIS Registry diagnoses as control.
Abbr. CI: confidence interval; OR: odds ratio; RAO: Retinal artery occlusion; TRAO: Transient retinal artery occlusion; PRAO: Partial retinal artery occlusion; BRAO: Branch retinal artery occlusion; CRAO: Central retinal artery occlusion; RVO: Retinal vein occlusion; VE: Venous engorgement; BRVO: Branch retinal vein occlusion; CRVO: Central retinal vein occlusion.