Fig. 5.

Silencing of CBX2 affects pathways tightly involved in cancer progression, including MAPK. A Pie chart showing upregulated and downregulated genes upon CBX2 knock-down. B GSEA analysis showing the top differential hallmark gene sets (nominal P < 0.05) related to shSCR and shCBX2 (NES = normalized enrichment score). C Simple track of representative differential genes with minimal 2-fold difference of key pathways upon CBX2 knock-down, including MAPK. D Heatmap analysis showing the co-occupancy of CBX2 and H3K27me3 at MAPK pathway regulatory regions in the indicated cell lines and in 6 different samples from AML patients