Table 1. Key Characteristics of Long Protofilaments Assembled from Planarized Insulin Monomers Belonging to Various Pseudo-2D Topological Categoriesa.
| category | inward directed termini | twist [deg.] | pitch [nm] | overall stability | H2O mol. per monomer |
|---|---|---|---|---|---|
| FC1 | N- (A-chain) | 0.1 | 1782 | + | 4.5 |
| FC2 | N-, C- (A-chain) | 0.0 | ++ | 3.5 | |
| FC3 | none | –0.9 | 198 | ++ | 3.5 |
| FC4 | C- (A-chain) | –1.1 | 162 | + | >20 |
| FC5 | N- (A-chain), N- (B-chain) | ND | ND | 2 | |
| FC6 | C- (A-chain), N- (B-chain) | –0.1 | 1782 | +++ | 1.5 |
a
Due to the instability of FC5 fibrils, the twist and helical pitch could not be determined (ND). The approximate number of potentially sequestered (within the central topological loop) water molecules is given per insulin monomer.