Figure 12.

Bayesian meta-analysis of 19 randomized controlled trials and 8 prospective observational studies showing the consistency of reduction of all-cause mortality between both study types in women who initiate hormone replacement therapy before age 60 years (29). Randomized controlled trials comprised of 16,283 women with mean age of 54.5 years at time of initiation of hormone replacement therapy; mean trial intervention was 5.1 years (1–6.8 years) with 83,043 women-years follow-up. Prospective observational studies comprised of 212,717 women with age range of 30–55 years at time of initiation of hormone replacement therapy; mean observation was 13.8 years (6–22 years) with 2,935,495 women-years of follow-up. CI = confidence interval