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Cochrane meta-analysis validates the Salpeter et al., meta-analyses (Fig. 6) showing similar reductions in all-cause mortality and coronary heart disease in women initiating HRT <60 years old and/or <10 years-since-menopause relative to placebo (26). Nineteen randomized controlled trials of 40,410 women comparing hormone replacement therapy of estrogen with or without progestogen with placebo. CI = confidence interval
