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Characteristics of Women in Observational Studies and Randomized Trials
| Observational Studies | Randomized Trials | |
|---|---|---|
|
| ||
| Mean age or age range at enrollment (years) | 30–55 | >63 |
| Time-since-menopause at HRT initiation (years) | <2 | >10 |
| Menopausal symptoms (flushing) | predominant | excluded |
| Duration of therapy (years) | >10–40 | <7 |
| Body mass index (mean, kg/m2) | 25.1 | 28.5 |
HRT = hormone replacement therapy
