Figure 3.

Significant deviation from healthy brain development in SUD. Significant mean MS deviations from normative development in five age categories in patients with SUD. Significance was determined using one-sample t-tests, FDR corrected at P < 0.01. Five age categories comprised 20–30-, 30–35-, 35–40-, 40–45- and 45–60-year-old participants. Those regions for which the quadratic trajectory provided a poor fit to the data (adjusted r²<0, see Supplementary material, Fig. 6) were excluded. Deviations (absolute t-statistics) consistent with accelerated ageing are shown in blue, whereas those inconsistent with ageing are shown in red (see Supplementary material, Fig. 7 for the deviations in the Cambridge control group).