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. 2022 Mar 28;4(3):fcac079. doi: 10.1093/braincomms/fcac079

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Brain-cognition association between MS and paired associates learning. Relationship between PAL, age, MS and stimulant drug use. The first two components of the PLS regression jointly explained 43.4% of variance in PAL total errors and age, and 4.35% of variance in regional MS in all 360 regions of interest. PLS2 explained a significant amount of variance in PAL performance and age (15.5%, P_perm = 0.02) but showed a strong positive association with PAL errors and a weak negative association with age (A). PLS1 also explained a significant amount of variance in PAL performance and age (27.9%, P_perm = 0.02) and was positively associated with both of these variables (B). The pattern of regional MS loadings on PLS1 (r = 0.385, P_perm = 0.37) and PLS2 (r = 0.165, P_perm = 0.44) was distinct from the pattern of the control versus stimulant use disorder group difference t-statistics (see Fig. 1C).