Table 1.
Characteristics of patients with diagnosis of malignancies and synchronous or metachronous Takotsubo Syndrome (TTS).
| Patient no. | Gender | Age* (years) | Malignancy | Obesity | Hypertension | Dyslipidemia | Diabetes mellitus | Previous or current smoker | COPD | Hyper- or hypothyroidism | Anxiety or depression | History of alcohol abuse | TTS before or after cancer diagnosis | Cancer treatment before TTS | Time between last cancer treatment and TTS | In-hospital complications | Cardiac resolution |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | F | 69 | Ovarian cancer | Yes | Yes | Yes | No | No | No | No | No | No | After (15 months) | Bevacizumab | 15 days | LVEF <45% | Yes |
| #2 | F | 58 | Lung cancer | No | No | Unk | No | Yes | No | No | No | No | Before (4 years) | – | – | n.e. | Yes |
| #3 | F | 80 | Non Hodgkin’s lymphoma | No | Yes | No | No | No | No | No | No | No | After (9 months) | Rituximab | 14 days | Right bundle branch block, LVEF <45%, thromboembolism | Yes |
| #4 | F | 63 | Lung cancer | No | Yes | No | No | Yes | Yes | No | No | No | After (1 month) | – | – | None | Yes |
| #5 | F | 59 | Glioblastoma | No | No | No | No | No | No | No | No | Unk | Before (3 years) | – | – | None | Yes |
| #6 | F | 73 | Breast cancer | Yes | Yes | Yes | Yes | Yes | No | No | No | No | Before (8 months) | – | – | None | Yes |
| #7 | F | 49 | Pancreatic cancer | Yes | Yes | Yes | Yes | Yes | No | Yes | No | No | After (1 month) | – | – | LVEF <45%, mitral regurgitation | Yes |
| #8 | F | 82 | Colon cancer | Unk | Yes | No | No | Unk | No | No | No | No | After (1 month) | Surgery | 1 month | LVEF <45%, mitral regurgitation | Yes |
| #9 | F | 90 | Chronic lymphatic leukaemia | Unk | Yes | Yes | No | No | No | No | Yes | No | Before (1 year) | – | – | None | Yes |
*Age at diagnosis of TTS.
Unk, unknown; COPD, chronic obstructive pulmonary disease; n.e., not evaluable; LVEF, left ventricular ejection fraction.